PGD/PGS
PGD/PGS Treatment in Miyapur
We are happy to announce the availability of the PGD/PGS tests at Lush Fertility.
We discuss all considerations on an individual basis with the patient, giving utmost attention to all factors involved in any fertility issue.
Before making any decision about genetic testing, we review each couple’s history and offer the most viable option to them.
Preimplantation Genetic Diagnosis (PGD) and Preimplantation Genetic Screening (PGS) are tests done on embryos for a particular genetic disease that they may be at risk of inheriting from the parents.
A biopsy is carried out for PGD/PGS.
For couples considering PGD/PGS Treatment in Miyapur, our fertility specialists review their medical and genetic history before recommending the most suitable testing option.
Embryo Biopsy
Preimplantation Genetic Diagnosis screens an embryo’s quality at the chromosomal and genetic level. It can be performed for a patient at high risk of carrying an inheritable genetic disease. Using this technique, embryos that do not carry the disease can be selected for transfer.
A single cell from an 8-cell stage embryo is removed and sent off for testing. DNA analysis identifies embryos that are free of the disease, making them good candidates for transfer.
Why is Embryonic selection beneficial?
For patients with genetic diseases, selection of embryos most likely to implant and develop into a healthy child becomes extremely important. Historically, the microscopic appearance of the embryo was the only criterion available to the physician and patient for selection of “healthy” embryos for transfer. Unfortunately, there is no correlation between embryonic appearance and genetic health. Perfect-appearing embryos can carry chromosomal abnormalities, and “unattractive” embryos can be genetically normal. The advent of PGD gave physicians and their patients with genetic disease an effective option for embryo selection.
Clinical indications for which PGD can be used include, but are not limited to:
- Aneuploidy testing for advanced maternal age and recurrent pregnancy losses (duplicated or missing chromosomes)
Embryo Biopsy for PGD and PGS
The process of IVF PGD as well as IVF PGS can be performed on embryos that are in different developmental stages; therefore, the biopsy procedure varies accordingly. In clinical practice, only two types of biopsy are used:
- Blastomere biopsy: On day three at the cleavage stage, 1 or 2 cells are removed from an 8-cell embryo for genetic analysis.
- Trophectoderm biopsy: On day five at the blastocyst stage, 4 or 5 cells are taken from the outer trophectoderm layer without affecting the inner cell mass from which the fetus later develops.
The biopsy procedure always involves two steps. The first is the opening of the zona pellucida, and the second is the removal of the cell(s). Both steps have different approaches, including mechanical as well as chemical procedures, but advanced laser technology is most commonly used for breaching the zona pellucida.
Using advanced technology, zona thinning is possible to create a point of herniation already at the time of ICSI procedure, which is less disturbing for the embryo than traditional zona opening. During trophoectoderm (TE) biopsy, we operate with an accurately controlled laser beam to release the outer cells of the blastocyst.
The retrieved embryonic cells are then sent for genetic analysis using the microchip method. In this, a larger number of cells allows a more accurate genetic assessment of the embryo without affecting its further development. Once the cells have been extracted from a blastocyst, the embryos are then frozen and stored for a few days until the genetic results are available. The main limitation of the process of blastocyst biopsy is that usually only a limited number of embryos will reach the blastocyst stage. Therefore, the final decision on the biopsy approach should be left to our experienced specialists.
The Benefits of PGD Are as Follows
- PGD can test for more than 100 different genetic conditions.
- PGD is performed before implantation, thereby offering the couple the option to decide whether or not they choose to go ahead with the pregnancy.
- PGD greatly reduces the risk of passing on specific genetic diseases to their biological offspring.
For couples looking for PGD/PGS Treatment in Miyapur, Lush Fertility provides individualized guidance based on medical history, genetic considerations, and fertility treatment needs.
Advantages that truly benefits you.
Class 10,000 state-of-the-Art IVF Lab
High success rates in IVF (40-60%)
Evidence based Practice
Advanced IVF lab equipment
Follows ICMR Guidelines Strictly
Transparency in Treatments
Ethical Practice Guidelines
Cost Effective Treatments
Individualised treatment
Empathetic
Approach
Miyapur, Hyderabad.
Lush Fertility, 3rd Floor, Prime Estate, Plot Number 209, Behind Metro Bus Stop, Opp: Miyapur Metro Station, Pillar No: A/620 Mathrushri Nagar, Miyapur.