Ovulation Induction & Follicular Study With Timely Intercourse
This is a basic step in the treatment of subfertility where medication is given to the female partner between day 2- day 5 for the development of one or more follicles (eggs) from the ovaries. The response to the medicine i.e the growth of the follicles is monitored with the help of serial vaginal scans .once the appropriate size is reached with adequate endometrial thickness uterus lining), HCG or agonist trigger Injection is given for maturation and release of the egg from the ovary And The couple is advised to have intercourse during the most fertile period of the cycle (i.e Timed intercourse) or planned for IUI. After an Hcg trigger, ovulation usually occurs 36–42 hours later and IUI is most commonly performed 32–36 h after hCG administration.
- For who? –women with irregular cycles, anovulatory cycles, pelvic endometriosis and hormonal disorders.
- Drugs used – clomiphene citrate, letrozole, with or without gonadotropin hormone injections. Some antioxidants and additional drugs may be prescribed as and when needed to enhance the response to treatment.
- Side effects / complications of ovulation induction drugs are rare and usually mild which include
- Hot flashes
- Mood swings
- Depression
- Breast tenderness
- Nausea
- Headaches
- Visual disturbances
- Weight gain
- Multiple pregnancy – upto 10% of women who use ovulation induction drugs have a risk of conceiving with twins (more common) or triplets or more.
- Ovarian hyper stimulation syndrome (OHSS) – mild OHSS occurs in less than 10 % women undergoing ovulation induction or controlled ovarian hyper stimulation where as severe form is rare and presents in only 1-2 % of women.
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